
Human Challenge Trials ∙∙
We hope with all our hearts that each one of you will display the same zeal to make your hope come true and that you will continue doing so until the end so that you may not become lazily lethargic but may copy those who, through faith and patience, inherit the promises. – Hebrews 6:11,12
Hebrews 6:9-12
9 Dear friends, even though we are talking this way, we really don’t believe it applies to you. We are confident that you are meant for better things, things that come with salvation.
10 For God is not unjust. He will not forget how hard you have worked for him and how you have shown your love to him by caring for other believers, as you still do.
11 Our great desire is that you will keep on loving others as long as life lasts, in order to make certain that what you hope for will come true.
12 Then you will not become spiritually dull and indifferent. Instead, you will follow the example of those who are going to inherit God’s promises because of their faith and endurance.
The Race for a Vaccine: A Global Challenge
With the onset of the global COVID-19 pandemic, the world faced an urgent need for a vaccine. Confidence was high that an effective vaccine could be developed, but initial projections estimated a timeframe of 12 to 18 months for thorough testing and approval for widespread use. During this period, millions of lives would be lost, and the virus would infect countless others.
An Unconventional Approach: Human Challenge Trials
In the midst of this crisis, an unconventional idea gained traction to accelerate vaccine development: human challenge trials. These trials involve volunteers receiving a potential vaccine and then being deliberately exposed to the virus to test the vaccine’s efficacy. While the concept seemed outlandish to some, it was not entirely novel.
In April 2020, 35 members of the U.S. House of Representatives urged the FDA to consider allowing such trials. The approach was likened to dangerous, even life-threatening missions undertaken during wartime. Despite the risks, the idea resonated with many.
A Global Response: Volunteers Step Forward
By late September 2020, the website 1daysooner.org had registered 37,254 volunteers from 162 countries, all willing to participate in human challenge trials. These individuals understood the risks, including the possibility of severe illness or death, yet they were motivated by the potential to save lives.
Scientists believed that such trials could significantly reduce the time required for final vaccine testing. However, many in the medical community viewed the proposal as “ethically unthinkable.” The idea of intentionally exposing humans to a deadly virus raised serious ethical concerns.
Altruism in Action: Sacrificing for the Greater Good
For the volunteers, it was an entirely different affair. Their focus was on the results, not the risk. Their decision was rooted in altruism. One volunteer remarked, “Times like these call for people who are able to be brave and put themselves forward for the greater good of society. This may be the defining period of my lifetime.” Their willingness to sacrifice for others is rare but not unprecedented, particularly in times of crisis.
REFLECT & PRAY
Self-sacrifice for the greater good may seem almost unheard. When does what is considered “ethically unthinkable” become an ethical imperative? The most remarkable and far-reaching act of self-sacrifice took place over two thousand years ago.
Father, thank You that You loved each of us individually enough to send the Lord Jesus Christ to die in our place, the One for the many. As a result, we will not perish but have everlasting life.
INSIGHT
The Precedent Was Set 2000 Years Ago
The most extraordinary, irrevocable example of self-sacrifice was set in 33 AD. Humanity, ruined by sin and helpless, was in need of rescue. Romans 5:8: “But God demonstrates His own love for us in this: While we were still sinners, Christ died for us.”
His sacrifice was the ultimate act of love and redemption, the One giving His life for the many.
Christ’s Sacrifice for Humanity
Mark 10:45: “For even the Son of Man came not to be served but to serve others and to give his life as a ransom for many.”
The Greek word translated as “ransom” in this verse is lutron, which refers to “the price paid to free slaves.” In the New Testament, the emphasis shifts from the payment itself to its results: redemption, deliverance, and release. This powerful idea highlights the liberty Christ secured for humanity through His sacrifice.
The word “for” in this verse is translated from the Greek word anti, which carries a deeper meaning. In addition to “for,” it can also mean “instead of,” “on behalf of,” “in place of,” or “in exchange.” This highlights the substitutionary nature of Christ’s sacrifice; He gave His life in our place.
The Lord Jesus Christ paid the ultimate price, laying down His life to provide redemption and release for all children of the King. This was not just an act of service; it was the greatest act of love in human history.
The Greatest Love of All
John 15:13: “Greater love has no one than this, that one lay down his life for his friends.”
While this verse speaks of the ultimate love one can show for their friends, Christ’s sacrifice went far beyond this. He did not die only for His friends; He died for the entire world.
John 3:16: “For God so loved the world, that he gave his only Son, that whoever believes in him should not perish but have eternal life.”
This act of love was not limited to those who loved Him in return. It extended to all humanity, even to those who were estranged from God. Christ’s death was the ultimate expression of altruism, surpassing any human example of self-sacrifice.
Christ’s Sacrifice
The apostle Paul reflects deeply on the unparalleled nature of Christ’s love and sacrifice.
Romans 5:5-8: “For we know how dearly God loves us because he has given us the Holy Spirit to fill our hearts with his love. When we were utterly helpless, Christ came at just the right time and died for us sinners. Now, most people would not be willing to die for an upright person, though someone might perhaps be willing to die for an especially good person. But God demonstrated his great love for us by sending Christ to die for us while we were still sinners.”
Paul emphasizes that Christ’s death was not for the righteous or the deserving but for sinners, those who were utterly helpless and undeserving of such grace. This sets Christ’s sacrifice apart from any other act of altruism in history.
Dying for Enemies: A Unique Sacrifice
One of the most remarkable aspects of Christ’s death is that He died for humanity while we were still enemies of God.
Romans 5:10: “For if while we were enemies we were reconciled to God by the death of his Son, much more, now that we are reconciled, shall we be saved by his life.”
The challenge before the Father and the Son was immense: how could they reconcile rebellious, defiant sinners to themselves? The answer was found in the death of the Lord Jesus Christ. The Father’s love made it “ethically imperative” to send His one and only Son as a sacrifice for the many. It was, in essence, a “suicide mission” undertaken for the sake of humanity.
The Result of Christ’s Sacrifice
Romans 5:18: “Christ’s one act of righteousness brings a right relationship with God and new life for everyone.”
Through Christ’s death, humanity was offered a way out of a hopeless situation. Sin had enslaved humanity, leaving no escape. But Christ’s sacrifice broke the deadlock, offering redemption and new life.
As William Barclay eloquently explains: “All humanity was involved in a situation from which there was no escape; sin had human beings in its power, and there was no hope. Into this situation came Jesus Christ, and he brought with him something that broke the old deadlock. By what he did, by what he is, by what he gives, he enabled men and women to escape from a situation in which they were hopelessly dominated by sin . . . it is completely true that the world was ruined by sin and rescued by Christ.”
A Love Beyond Comprehension
The sacrifice of the Lord Jesus Christ is an extraordinary act of love and redemption. It was more than just an act of kindness; it was a divine intervention designed to rescue humanity from the grip of sin. Through His death, Christ provided a way for everyone to be reconciled to God, offering eternal life to those who believe.
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© Dr. H 2025